delta-8-THC

Naturally occurs in very low amounts in hemp

Produced from CBD in hemp using a chemical solvent

Relaxation without a high (although higher dosages may produce a high feeling)

FDA reports adverse events including vomiting, hallucinations, trouble standing, and loss of consciousness.

Some products, like vapes, can be extremely sedating

Currently legal in most states, alhtough regulations are in development. 

 

THC-O or THCo actetate

Man-made analog of delta-9-THC

May contain harmful chemicals from the production procedure

Advertised to be 300X stronger than THC  (Ethan Russo says 2X as strong)

The Edgewood Arsenal facility in Maryland between 1949 and 1975 used THCO in experiments.

Ethan Russo is quoted in HempGrower magazine saying “what is needed when you’re using a drug to stimulate the system is a gentle nudge, not a violent push that comes from something that is a lot stronger than THC itself.”

Article: THC-O Acetate Q&A with Dr. Ethan Russo: ‘Don’t Go There’, Jolene Hanson, 8/3/21 https://www.hempgrower.com/article/thc-o-acetate-q-and-a-dr-ethan-russo-credo-science/

It is a derivative of hemp, so legal for now.

THCP

Has a longer side chain link:  7 links instead of 5 links which may create a greater affinity than THC for binding to CB receptor

(minimum of 3 links needed for binding – max of 8 links before affinity starts to decrease)

In 2020, a group of Italian researchers used new technology to discover two new cannabinoids:  THCP (tetrahydrocannabiphorol) and CBDP (cannabidiphorol)

THCP was 33 times more active than regular THC on the CB1 receptor, and 5-10 times more active than regular THC on the CB2 receptor. 

CBD does not bind well to CB1 or CB2 receptors so the longer side chain does nothing for binding- but who knows

This information was obtained on Leafly. Read more here:

https://www.leafly.com/news/science-tech/thcp-cbdp-study-reveals-identification-two-new-cannabinoids

THCB and CBDB

Identified by Italian researchers using spectrometry on a Cannabis Sativa variety produced by the Military Pharmaceutical Plant in Florence.

THCB has a higher binding affinity with CB1 over delta 9-THC